I went all over San Diego and loved it, but find LA trips need to be very localized. I've really enjoyed trips to Orange, just outside of Anaheim, and the little downtown area that doesn't at all feel like you're surrounded by a billion people. Spent time in Pasadena for work and enjoyed it, plus some time in the Ventura area (which really isn't LA).
There are peaceful pockets in all the chaos and some of the best food & beer in the world.
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